Nabil Seidah

Scientist, Person

1949 –

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Who is Nabil Seidah?

Nabil G. Seidah, CM OQ FRSC is a Québécois scientist. Born in Egypt, he was educated at Cairo University, and subsequently at Georgetown University where he obtained his Ph.D in 1973. He emigrated to Canada and has been working at the Clinical Research Institute of Montreal since 1974. He is the director of the laboratory of Biochemical Neuroendocrinology. Dr. Seidah discovered and cloned seven of the nine known enzymes belonging to the convertase family. During this period, he also greatly contributed to demonstrating that the proteolysis by the proprotein convertases is a wide mechanism that also concerns “non-neuropeptide” proteins such as growth factors, α-integrins, receptors, enzymes, membrane-bound transcription factors, and bacterial and viral proteins. Recently, he showed that point mutations in the PCSK9 gene cause dominant familial hypercholesterolemia, likely because of a gain of function related to the ability of PCSK9 to enhance the degradation of cell surface receptors, such as the low-density lipoprotein receptor.

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Born
1949
Egypt
Nationality
  • Canada
Profession
Education
  • Georgetown University
  • Cairo University

Submitted
on July 23, 2013

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"Nabil Seidah." Biographies.net. STANDS4 LLC, 2021. Web. 6 Dec. 2021. <https://www.biographies.net/people/en/nabil_seidah>.

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