Paolo Zamboni

Who is Paolo Zamboni?

Paolo Zamboni is an Italian doctor who claims to have found in an unblinded preliminary study that in over 90% of the participants with multiple sclerosis there were problems in veins draining their brain, like stenosis or defective valves. He also noticed high level of accumulation of iron deposits in the brain, supposedly due to restricted outflow of blood.

According to Zamboni some symptoms of multiple sclerosis in his own wife as well as 73% of his patients abated after an endovascular procedure to open these veins.

Zamboni named this condition chronic cerebrospinal venous insufficiency.

The theory is controversial. The National Multiple Sclerosis Society has said that, while "there is not yet enough evidence to conclude that obstruction of veins causes MS," that "[Zamboni's] hypothesis on CCSVI and its corrective treatment is a path that must be more fully explored and one that we are supporting with research funding." Since 2010, there has been more research that disputes the Zamboni theory.