Barry Posner

Who is Barry Posner?

Barry Innis Posner, OC FRSC is a Canadian physician, research scientist and Professor in the Departments of Medicine, Anatomy & Cell Biology, and Director of the Polypeptide and Protein Hormone Laboratory at McGill Univ. Born in Winnipeg, Manitoba, he received his Doctor of Medicine from the University of Manitoba in 1961. A gold medalist in his graduating class, Posner pursued post-graduate work at the Massachusetts Institute of Technology, and the National Institutes of Health in Bethesda, MD before joining the Royal Victoria Hospital and the McGill Univ. Faculty of Medicine in 1970 as an assistant professor. He was appointed an Associate Professor in 1975 and a Professor in 1979. He is currently the Director of the Polypeptide Hormone Laboratory at McGill University and a Professor in the Department of Medicine and the Department of Anatomy and Cell Biology as well as senior physician at the Royal Victoria Hospital. He has served as Director of the McGill Endocrine training program and physician-in-chief at the Sir Mortimer B. Davis Jewish General Hospital.

His fundamental research on insulin signaling led to the discovery of the endosomal system and the view that this is a central site for both initiating and regulating signal transduction. In the late 1980s he discovered the peroxovanadium compounds as potent insulin mimetics; and in elucidating their mechanism of action defined the key role of phosphotyrosine phosphatases in regulating Receptor Tyrosine Kinases. His group went on to define the role of lipid rafts as sites of intense signaling at both the cell surface and within endosomes. More recently Posner’s diabetes research focused on the genes responsible for diabetes, the discovery of which will aid in the prediction and treatment of this disease.