Pier Paolo Pandolfi

Who is Pier Paolo Pandolfi?

Dr. Pier Paolo Pandolfi is an award-winning research geneticist at Beth Israel Deaconess Medical Center, a major teaching hospital of Harvard Medical School. The research carried out in Dr. Pandolfi’s laboratory has been seminal in defining the molecular mechanisms and the genetics underlying the pathogenesis of APL, lymphomas, and solid tumors, as well as in modeling these cancers in the mouse. Dr. Pandolfi and colleagues characterized the function of the fusion oncoproteins of APL, of the genes involved in the chromosomal translocations of APL, as well as of major tumor suppressors such PTEN, PML, and p53. The elucidation of the molecular basis underlying APL pathogenesis has led to the development of novel therapeutic strategies that are currently being tested in clinical trials.