Brian Matthews

Who is Brian Matthews?

Brian W. Matthews is a biochemist and biophysicist educated at the University of Adelaide, contributor to x-ray crystallographic methodology at the University of Cambridge, and since 1970 at the University of Oregon as Professor of Physics and HHMI investigator in the Institute of Molecular Biology.

He created hundreds of mutants of T4 lysozyme, determined their structure by x-ray crystallography and measured their melting temperatures. Starting from questions about the basis of "temperature-sensitive" mutations, his work has explicated much about the general energetic and structural effects of mutations in proteins. He also solved early structures of the thermophilic bacterial enzyme thermolysin, the Helix-turn-helix DNA-binding transcription factor lambda Cro repressor, and the light-antenna bacteriochlorophyll protein. Dr. Matthews has been a member of the National Academy of Sciences since 1986. He is the editor of the scientific journal Protein Science.