Alfred G. Knudson

Who is Alfred G. Knudson?

Alfred George Knudson, Jr. M.D., Ph.D. is a geneticist specializing in cancer genetics. Among his many contributions to the field was the formulation of the Knudson hypothesis in 1971, which explains the effects of mutation on carcinogenesis.

Born in Los Angeles in 1922, Knudson received his B.S. from California Institute of Technology in 1944, his M.D. from Columbia University in 1947 and his Ph.D. from California Institute of Technology in 1956. He held a Guggenheim fellowship from 1953 to 1954. From 1970 to 1976, Knudson served as the Dean of Graduate School of Biomedical Sciences, University of Texas Health Science Center at Houston. He has been affiliated with the Fox Chase Cancer Center in Philadelphia since 1976.

He received numerous prizes and honorary doctorates for his work, most prominently the 1998 Albert Lasker Award for Clinical Medical Research. He also received the 1999 American Society of Pediatric Hematology/Oncology Distinguished Career Award, the 2005 American Association for Cancer Research Award for Lifetime Achievement in Cancer Research, and the 2004 Kyoto Prize in Life sciences.